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Literature summary extracted from

  • Sharma, M.; Batra, J.; Mabalirajan, U.; Sharma, S.; Nagarkatti, R.; Aich, J.; Sharma, S.K.; Niphadkar, P.V.; Ghosh, B.
    A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma (2008), Am. J. Respir. Crit. Care Med., 177, 712-719.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.66 medicine INPP4A is identified as a novel asthma candidate gene Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.66 additional information a nonsynonymous single nucleotide polymorphism +110832A/G (Thr/Ala) present within a PEST sequence (peptide sequence rich in proline, glutamic acid, serine and threonine), shows a significant association with atopic asthma. INPP4A alpha3 protein variant from platelets of individuals with AA genotype is found to be more susceptible to degradation, whereas the protein from individuals with GG genotype is less susceptible. Also, the basal levels of INPP4A protein in platelets from individuals with AA genotypes is found to be lower, suggesting poor stability in vivo as well Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.66 Homo sapiens Q96PE3
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.66 blood platelet
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 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
3.1.3.66 inositol polyphosphate 4 phosphatase A
-
 Homo sapiens
3.1.3.66 INPP4A
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 Homo sapiens